Nanocrystal (Nanoparticles) Drug Delivery in Oncology

Nanocrystal (Nanoparticles) Drug Delivery in Oncology Introduction The aim of this literature review is to expand the boundaries of our knowledge by exploring some relevant literature related to the role of nano-particle in cancer treatment and toxicology. In this paper, the author will discuss the importance of nanocrystals in treating and managing cancers. For this, the author will refer to three different scholarly articles. Heidel Davis, (2011) accentuated that the treatment of cancer is complicated by the exact nature of the cancer cells, the tissue they originate from, and the tissue or tissues they hibernate and colonize in [1]. Many cancers, such as those affecting the colon or liver, remain tucked away in the darker recesses of the body, where they are challenging to detect and even more challenging to treat. Other cancers, such as melanoma or retinoblastoma, are at or near the surface of the body, and thus are more accessible to observation and treatment. All cancer therapies try to target characteristics that are peculiar to cancer cells so as not to damage normal cells. This could be a mutated protein, a peculiar behaviour pattern, such as an increased rate of cell division, or an elevated demand for oxygen to support high metabolic activity by the cancer cells [2]. Discussion Analysis Over 8,767 Australians were expected to die of cancer in 2020 [3]. Over 12 million new cases worldwide were diagnosed in 2007. Sixty percent of cancer cases occur in developing countries. Cancer is on the rise in low- and middle-income countries, cancer is the number one cause of death in China. According to Phan et al., (2009), chemically attached nanocrystals to a viral envelope allowed the scientists to eradicate cancer cells using laser radiation [4]. Binding nanoparticles to an antibody specific for cancer cells can make easier the detection of advanced stage cancer cells. According to Colin, (2008), the ability to quantitatively and noninvasively detect targeted nanoparticles in vivo could provide a promising cancer diagnostic tool. Using nanoparticle to heat up tumors is a main focus in therapeutic oncology applications of nanoscale sciences and technologies [5]. Nanosized Cancer drug Nanocrystal helps in the advancement of creative chemotherapeutic medications particularly in the territory of harmful deteriorating treatment or solution for neurological issue or cancerous growth. It delivers nanosized medications that are just marginally bigger in size than proteins and are subsequently little to such a degree as to move crosswise over ion-control channels(e.g., the blood–brain barriers), scattered all through the entire body including entering the focal sensory system, the vasculature and enter cells specifically [6]. Nanosized pharmaceuticals, due to their greater surface territory and organic undertaking likewise allow lower centralizations of pharmaceuticals to be utilized; accordingly diminish the potential danger of unfavorable responses [7]. The propelled outside area of nanosized pharmaceuticals might likewise help to upgrade dissolvability and support rate of disintegration, in this manner increase oral bioavailability and allow all the more quick onset of remedial activity [8]. A showing of this future is the adaptation of naproxen that have been used to support the expand time in the blood of the patients to empower a great deal more quick issue and help than the acknowledged presentation of naproxen for their cancer treatment [9]. Nano consignment schemes for therapeutics and toxicology Numerous advances have been created to utilize nanoparticles as a part of the treatment regimen of biomedical imaging, toxicological analysis and pharmaceutical conveyance. Applications for these plans will supply materials for controlled medication committal by directing bearers to a particular area with attractive fields or fluorescence biological markers. The transporter will then be initiated on interest in a limited area. The anticipated and extended length of activity in this way help to abatement hindrance of basic redosing, advance patient consistence and keep away from the side effects that so regularly result from intense medications [10]. Use of Nanocrystal in Oncology The interstitial heating using nanoparticles was feasible in patients with cancer with local recurrence and had been previously irradiated. The treatment related toxicity was moderate and the quality of life affected only temporarily. The limiting factors of this technique at present are discomfort caused by high magnetic field strengths and suboptimal intratumoral distribution. Moreover, deposits in the prostates nanoparticles are very durable. At present there is no magnetic imaging and chemotherapy available or neither for direct injection of fluid under visual control real-time nor for a reliable picture of the tumor within the cancer cells. Therefore, the selective ablation of cancer separating normal tissue is not possible at this time, but may become an interesting future with improved diagnostic techniques image subject. Until our heating method is more refined and can be safely applied forces higher photo thermal therapy to achieve higher performance alone, this treatment modality is being evaluated in combination with radiation in patients with localized cancer. Quantum spots, one of the most well revised, are nanocrystals that fluoresce in distinct hues depending on their dimensions (e.g., Cadmium selenide) [11;12]. In the event that the target molecule is an early marker of cancerous detection, discovery of that molecule may show a higher inclination for illness. An illustration is to utilize nanoparticles to join to blood clumps and to help make clusters more clear by ultrasound [13]. Nanoshells, an alternate nanodelivery plan that is made out of copolymers, are used in mix with precise wavelengths of lights and hotness mastery for harmful ailment treatment. These nanodevices can be tuned precisely to drench up or scramble infrared beams. At the point when encased in with gold, they can adjust these types of light into high temperature and either issues the pharmaceutical into the encompassing tissue or specifically blazed/murder tumor units that is tie to these nanoshells [14]. Likewise, attractive fields could be used to center pharmaceutical particles at the tumor area and balancing the territories would discharge the pharmaceutical from the external layer to strike tumor units. Chemotherapeutic Drugs and Cancer Diagnosis Infusion of genetic characteristics into nanocapsules is being tried out. One of the quality being enquired is the tumor necrosis factor, a protein that is fatal to cancer cells as well as besides to wholesome units when infused in substantial measurements [15]. To sidestep impedance to ordinary tissue, the nanocapsule is covered with sensors that objective just on tumor cells. A persevering would then be uncovered to low-dose radiation or medications that launch the quality to make putrefaction part. Other nanodrug bearers, for example, quality firearm with gold particles, fullerenes (made completely out of carbon, as an empty circle (C60 Bucky balls or chamber (nanotubes) and dendrimers (round polymeric molecules) are likewise being inspected. An alternate mean of pharmaceutical conveyance is to settle pharmaceutical with nanoparticles, for instance albumin proteins. It uses the natural carrier albumin rather than synthetic solvents to consign paclitaxel and furthermore for protected management of high paclitaxel doses without premedication, producing in important antitumour undertaking in patients with metastatic breast cancerous disease. Nanodelivery schemes for gene therapy Nanomedical research could outcome in an array of new medical apparatuss. Interesting study projects include use of nano-electromechanical apparatus or nanowire field-effect transistor to detect insect baculovirus and lone influenza viruses respectively were undertook. It is wanted that development of these nanodevices can help doctor to find the difficulty areas in the body more precisely (Lam et al., 2004, p. 5). Other study works engage the use of biochips and microfluidic devices to computer display tissues for genetic dissimilarities and to design genetically target drugs. Cell/Tissue technology and the nanorobot Artificial nanoscale building blocks may one day be utilised to help repair, sustain, or replacement of the body’s tissue and body parts. Uvocalise nanotechnology, researcher may be adept to make better artificial veins, arteries and heart valves; evolve a scaffold for growing patches of heart tissue to repair impairment from heart attacks; and grow artificial lung tissue. The use of simple carbon single-wall nanotube sheets to develop artificial muscle is in the soonest stages [16]. One of the more significant matters is that the foreign components might be strike by the body’s immune units, therefore means of reducing the risk of immune answer continues the major dispute for nanotechnology research in the area of tissue technology. Some researchers are attempting to assemble convoluted nanorobots that can journey throughout the human body utilising molecular engines and computers, shop and transport substances, perform procedures and communicate with physicians. Respirocytes, a spherical carbon nanorobot, is an demonstration that mimic the activity of the natural hemoglobin-filled red blood cells and is being revised [17]. However, despite the stride at which study is progressing and the exhilaration generated by the outlook of nanorobots, it could be numerous years before nanorobots are checked in humans. Conclusion Cancer is a worldwide problem. Nanocrystal plays an increasing role in battling cancer worldwide and in achieving the goal of eliminating suffering and death from cancer by 2015. Moreover, the use of multifactorial Nanocrystal in detecting and diagnosing carcinomas and sarcomas at earlier stages can be beneficial but needs further studies and investigation before implementing it in clinical practice. The general is for government to assume a main part, at the same time with the educated community and business relationship, in adding to the empowering foundation for perceiving and considering nanomaterial potential dangers, including (1) ID of delegate or structure nanomaterial, in connection to the structure, measurements, property and undertaking; (2) creating poisonous quality testing convention, covering inward breath, dermal, ingestion, and infusion presentation courses, for ID of full gimmick of the nanomaterial in connection to material property, the proposed use by the conceiv ably inclined, helpless patient and a definitive clinical applications; (3) strengthening the building methodologies under Good developing perform (GMP) for nanomedicine in particularly in the zone of creation, pontoons, taking care of and stockpiling to twofold watch that relentlessness and nature of the last stock is supported; (4) recognizing and administering the introduction level in working environment, air/waterborne discharges, people and different life forms and ecological media; and (5) surveying the impact of nanocyrstal items on the indigenous habitat as a proactive danger administration. Early theoretical and experimental studies of the biocompatibility of nanomaterials and sophisticated nanodevices have begun. References 1. Heidel, J. D., Davis, M. E. (2011). Clinical developments in nanotechnology for cancer therapy.Pharmaceutical research,28(2), 187-199. 2. Misra, R., Acharya, S., Sahoo, S. K. (2010). Cancer nanotechnology: application of nanotechnology in cancer therapy.Drug Discovery Today,15(19), 842-850. 3. Staples, M. P., Elwood, M., Burton, R. C., Williams, J. L., Marks, R., Giles, G. G. (2006). Non-melanoma skin cancer in Australia: the 2002 national survey and trends since 1985.Med J Aust,184(1), 6-10. 4. Phan, J. H., Moffitt, R. A., Stokes, T. H., Liu, J., Young, A. N., Nie, S., Wang, M. D. (2009). Convergence of biomarkers, bioinformatics and nanotechnology for individualized cancer treatment.Trends in biotechnology,27(6), 350-358. 5. Colin D. Medley, Joshua E. Smith, Zhiwen Tang, Yanrong Wu, Suwussa Bamrungsap, and Weihong Tan* (2008), Gold Nanoparticle-Based Colorimetric Assay for the Direct Detection of Cancerous Cells, Anal. Chem, 80, pp. 1067-1072 6. Chen et al., 2006 Z. Chen, H. Meng, G. Xing, C. Chen, Y. hao, G. Jia, T. Wang, H. Yuan, C. Ye, F. Zhao, Z. Chai, C. Zhu, X. Fang, B. Ma and L. Wan, Acute toxicological effects of copper nanoparticles in vivo, Toxicol. Lett. 163 (2006), pp. 109–120. 7. Bucolo et al., 2002 C. Bucolo, A. Maltese, G. Puglisi and R. Pignatello, Enhanced ocular anti-inflammatory activity of Ibuprofen carried by an Eudragit RS100 nanoparticle suspension, Ophthal. Res. 34 (2002), pp. 319–323. 8. Alexis, F., Rhee, J. W., Richie, J. P., Radovic-Moreno, A. F., Langer, R., Farokhzad, O. C. (2008). New frontiers in nanotechnology for cancer treatment. InUrologic Oncology: Seminars and Original Investigations(Vol. 26, No. 1, pp. 74-85). Elsevier. 9. Aliosmanoglu, A., Basaran, I. (2012). Nanotechnology in cancer treatment.J Nanomedicine Biotherapeutic Discov,2, 107. 10. Donaldson et al., 2004 K. Donaldson, V. Stone, C.L. Tran, W. Kreyling and P.J.A. Borm, Nanotoxicology, Occup. Environ. Med. 61 (2004), pp. 727–728. Full Text via CrossRef (144) 11. Ferrari, M. (2005). Cancer nanotechnology: opportunities and challenges.Nature Reviews Cancer,5(3), 161-171. 12. Barlow et al., 2005 P.G. Barlow, K. Donaldson, J. Maccallum, A. Clouter and V. Stone, Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration, Toxicol. Lett. 155 (2005), pp. 397–401. 13. Gmeiner, W. H., Ghosh, S. (2014). Nanotechnology for cancer treatment. Nanotechnology Reviews,3(2), 111-122. 14. Bulte, J.W, (2009), Nanoparticles in Biomedical Imaging: Emerging Technologies and Applications. New York, Springer, pp. 2. 15. Wang, X., Yang, L., Chen, Z. G., Shin, D. M. (2008). Application of nanotechnology in cancer therapy and imaging.CA: a cancer journal for clinicians,58(2), 97-110. 16. Gmeiner, W. H., Ghosh, S. (2014). Nanotechnology for cancer treatment. Nanotechnology Reviews,3(2), 111-122. 17. Bucolo et al., 2002 C. Bucolo, A. Maltese, G. Puglisi and R. Pignatello, Enhanced ocular anti-inflammatory activity of Ibuprofen carried by an Eudragit RS100 nanoparticle suspension, Ophthal. Res. 34 (2002), pp. 319–323.

The Pearl

Assignment 1 † Money is the root of all evil†. To what extend is this one of the themes of the novel you studied. The Pearl by John Steinbeck – The theme of Greed Nurain Ariff This theme emerges the moment the people of La Paz get to know about Kino's pearl and we begin to see changes in the characters. All of them have their own selfish schemes when they learn about Kino's pearl. When they know that Kino has the pearl the village of La Paz is alive with avarice. Everyone wants something from Kino. Everyone was affected and wanted something from the pearl.Kino was the only one in the way. The doctor wanted money for â€Å"curing† the child. The priest wanted money to fix the church. The shopkeepers, the pearl buyers, and the rest of the town wanted money for their own purposes. The pearl was a poison that ruined many good people and made the evil people worst. The doctor is pure evil. He would not treat Kino's baby because Kino had nothing to pay him with. W hen the doctor heard of Kino's sudden wealth, he said Kino was his client. As he visualized life back in Paris all he could think of was getting enough money to be able to go back again.When he went to see Kino, he even made up a fake symptom of death to scare Kino into letting him â€Å"treat† the baby. Instead, he poisoned the baby and cured him of the poison he had given the baby himself. This horrible doctor is filled with avarice. He did not care who he had to harm to get more money. All he cares about is money. The priest wanted money to fix the church. Even the priest, a person who is highly regarded in the community, has some plans on how to use the money from the sale of the pearl. It is only after this that he thinks how the pearl will affect Kino's personal life.The priest is nearly as bad as the doctor. He also wanted money from Kino. He thinks  of certain repairs necessary for the church. He wondered what the pearl would be worth. And he wondered if he had bapt ized Kino’s baby, or married him for that matter. He thought if he did these things he was more likely to get money to fix the church. The priest calls on Kino and his family. He reminds them that they should show their gratitude to God for this unexpected gain and to pray for guidance in the future. Juana agrees and says that they will be married in the church.The priest is also a horrid person; he is supposed to be a holy figure, but he was poisoned by the thought of riches. These hopes caused him to lie. The new riches also affected the townspeople. The shop keepers hear about Kino's wealth and hope to sell their clothes. They knew that an indigent man that becomes rich by luck knows how it feels to be poor. Therefore, they would get money too. The pearl buyers were also full of avarice for the pearl. They wanted to buy the pearl for a very low price so they were cheating Kino. They hoped that if they bought the pearl, the boss would promote them and they would make more m oney.Everyone wanted something from the pearl. Kino became the whole town's enemy because of that. The effects of greed  after Kino finds the pearl are he learns how far others will go, including committing murder to gain wealth and the power that it brings. All those who hear about the pearl, even his neighbours  Ã¢â‚¬Å"suddenly became related to pearl, and pearl went into the dreams, the speculations, the schemes, the plans, the futures, the wishes, the needs, the lusts, the hungers, of everyone. † And since Kino stood in their way, â€Å"he became curiously every man's enemy. Kino recognizes this desire in himself, not for wealth, but for the power the pearl can grant him. He says the pearl is his soul. Comments: Good elaboration of points. However, do you actually know the meaning of the word ‘avarice’ you use in the essay? Why don’t you just stick to the common word ‘greed’? Just in case you use it in the wrong context? Overall, good attempt 😉 Taufiq In the novel The Pearl written by John Steinback, one of the themes is money is the root of all the evil because when Kino found the pearl everyone has a bad idea on how to manipulate Kino and become rich such as the doctor who is greedy.Before Kino had money to treat his son ,Coyotito, he was very evil and later when Kino found the Pearl he took the advantage of Kino to take the pearl that Kino would sell and poisoned his son to convince Kino to let him treat Coyotito . The priest is also evil when he needs the money to repair the church. He used the tactics so that he could have that money by saying that Coyotito should be baptised in the church and Juana and Kino should marry legally in the church. The pearl buyers are also evil when they know that Kino has found the greatest pearl that is also their source of income.They became very greedy and offered the lowest price to Kino so that they will get more income. Comments: A lot of grammatical errors can be found in your answer. Most of your sentences are also confusing and the meaning is not clear. Try to write simple and short sentences with less error. Make sure you organize your ideas before writing them. Faiqa From the novel that I studied, The Pearl by John Steinbeck, the phrase â€Å"Money is the root of all evil† is shown in the theme of greed. The doctor in this novel is an example of a greedy person.In the beginning of the novel, the doctor refused to treat Kino's son, Coyotito, who had been stung by a scorpion as he knows Kino will not be able to pay him for the service. To him, the natives or the ‘Indians' are nothing more than animals. However, after the discovery of the Pearl of the World, the doctor suddenly becomes concerned about Coyotito's health. He even goes as far as to visit the sick baby at Kino's brush house. All this is done purely because of his greed. He is hoping that by doing this, Kino will feel indebted to him. He is also certain that Kino w ill be able to pay him now.The priest is also a greedy person. Before the discovery of the pearl, the priest does not seem to be too interested in the affairs of the natives. However, after the discovery of the pearl the priest makes the effort of visiting Kino to remind him of his duties. The priest's visit is actually to ensure that Kino will donate some money so that repair works can be carried out at the church. To a certain extent, I think this phrase is exposes the fact that greed brings out the worst in man. It can also be used to describe Kino's characteristic.Before the pearl was found, Kino was contented with his life. The scene at the beginning of the novel shows how Kino's life is peaceful. Kino is also protective over his family before he found the pearl. The description of him killing the scorpion shows how protective he is to his son. Not only is he caring and gentle with his family, he also takes good care of his belongings, for example, his canoe. But, after the dis covery of the pearl, Kino becomes as cold and deadly as steel. He is willing to kill, first the attacker and then the trackers, in order to guard his pearl from falling into their hands.Kino's character in the novel slowly changes and the author likens his behaviour to that of animals'. He is suddenly described as a snake after he hits and kicks Juana when the latter tries to throw the pearl back into the sea. Later, he is described as a lizard as he edges his way closer to the trackers before killing all of them. Finally, Kino becomes fierce and violent as the story progresses. He is ultimately described as a terrible killing machine before he kills all the trackers. Comment: Good elaboration. Some minor grammatical error can be found in the essay. Nur AliaThis theme emerges the moment the people of La Paz get to know about Kino's pearl and we begin to see changes in the characters. All of them have their own selfish schemes when they learn about Kino's pearl. Even the priest, a pe rson who is highly regarded in the community, has some plans on how to use the money from the sale of the pearl. It is only after this, that he thinks how the pearl will affect Kino's personal life. Since Kino is the only one who stands in the way of the others by possessing the pearl, he becomes every man's enemy. The doctor makes Coyotito ill so that he can then ‘treat' Coyotito and ask for payment from Kino.Out of greed, he has betrayed the nobility of his profession. The pearl buyers conspire to cheat Kino so that they can make bigger profits. Unidentified people, envious of Kino's pearl, attack him physically and damage his possessions. His house is ransacked and burnt down. This leaves him no choice but to abandon the safety of his community and travel into the unknown. Even Kino himself is affected by the pearl, although he plans to use it to better himself and his family's situation, he becomes obsessed with it and turns violent, even against Juana.He becomes a changed person. He is filled with anger, turning animal-like and â€Å"hissed at Juana like a snake†, when she tried to throw the pearl he beats her up and kicks her. Comment: A lot of spelling error found in your answer. Please make sure that you recheck your essay before submitting it next time. Syazwan Based on the novel that I had studied, money is the root of all evil. Kino had found the big pearl when his son Coyotito was bitten by the scorpion. The theme of greed can be seen when the villagers knew about the big pearl.Kino tried to find good treatment for his son. The greedy doctor only wants the money as he is a selfish person. Kino tried to sell the pearl at town. The dealers only offer him a low price although they know the pearl is of a good quality. Kino was attacked by the attacker Kino saved himself when he killed the attacker. The pearl gives many problems to Kino and his family. Lastly, Coyotito was killed and Kino throws back the pearl into the sea. Comment: Your an swer does not really fulfil the requirement of the question. The ideas are there but you did not explain them clearly.Please refer to your friends’ answer which received good comments from me. Ayuni In the Pearl, â€Å"Money Is the root of all evil† represents the theme of greed. The doctor refused to treat Coyotito for the scorpion’s sting as Kino has no money. After Kino’s discovery of the pearl the doctor claims that Coyotito is his patient and pretended to ‘ treat' the baby . The doctor was just only thinking about money. The Pearl buyers planned to cheat Kino. They offer Kino a very low price for the pearl. They say that the pearl is too soft and chalky and will lose its colour.They only want to get more profit. The priest came to Kino after knowing about the discovery of the great pearl. He always thought of the church, and used religion for selfish ends. The thief and trackers tried to steal the pearl from Kino until violence happens. Kino ha s also become a greedy person. He does not listen to Juana when she asked him to throw back the pearl before many evil happened to them. Comment: Your answer is quite okay. Make sure you elaborate a little bit more in your exam so that your ideas will be more organized. Fatin NabilaMoney is the root of all evil. The theme greed and selfishness is the theme that is extended to it. The doctor in the novel is an example of a greedy person. The doctor refused to treat Coyotito because he will not work for free. The doctor is only interested in treating Coyotito after he knows about great pearl that Kino has discovered. Moreover, the attackers and trackers are also greedy. They attempt to steal the pearl from Kino. The priest is also a greedy person. Before the discovery of the pearl, the priest does not seem to be too interested in the affair of the natives.However, after the discovery of the pearl the priest’s visit is actually to ensure that Kino will donate some money so that repair works can be carried out at the church. Comment: Your ideas are largely organized and supported. However, your answer would be more solid if you include more examples as there are a lot of characters which portrayed greed in the novel. Faris One of the themes represented in the novel The Pearl is greed. It can corrupt people. Kino found a strange pearl, and this is a good thing for Kino and his family. He hopes for a quality treatment for his son, Coyotito who was stung by an evil scorpion.He wanted to marry Juana in a church and give education to his son when he grows up. The news about it was heard by the villagers including the doctor, the priest, and the pearl buyers. At first the pearl symbolizes hope and triumph but at last it showed how men were overcame by greed when the pearl was known by the villagers. They wanted the pearl for their own use. Because they wanted the power and have the power, they would do anything to get the pearl because it is a great pearl. The pe arl made them become so greedy. It shows that the money is the root of all evil.It can be seen when Kino killed the trackers who wanted to steal it. At last, Coyotito died when the tracker shot him thinking he was a coyote pup. Comment: Quite good. Please pay more attention to grammar and sentence structure. Fatin Inani One of the themes represented in The Pearl is greed. It corrupts people. Kino finds a rare pearl, and this is a good thing for him. He hopes for quality treatment for his baby who had been stung by a scorpion. He hopes that he and Juana will now be able to afford a proper wedding, as well as a better quality of life.He hopes for power and respect from others, too, as seen in his desire to get a rifle. Most of all, he hopes to give his son a good education that will ensure him a good future and enable him to look after the interests of the simple village folk. The pearl is at first, a symbol of hope and triumph, but because of the greed of men, it soon becomes a symbo l of corruptibility and evil desires of man. In itself, it is not an evil thing, but the evil, selfish desire of greedy men turn into an ugly thing. Even the kind, noble, well-liked Kino falls under the power of the pearl.Here, we see a related theme, the theme of the corruptibility of man. Kino becomes obsessed with the pearl because it holds so much promise for him and his family. It blinds him to the simple beauty of his life. Juana begs him to throw it back into the sea, but he refuses. He says that it has become his soul and he cannot part with it. Comment: A good answer. Take this answer as one of the good example on how to tackle this question. Azuren The theme of greed emerges the moment the people in La Paz get to know about Kino's pearl and we begin to see changes in the characters.All of them have their selfish schemes when they know about the pearl. Even the priest, a person who is highly regarded in the community has plans on how to use the money from the sale of the pe arl. Since Kino is the only one who stands in the way of the others by possessing the pearl, he becomes every man's enemy. Therefore, many attempts are made to get rid of him. The greed of the people makes them willing to do anything to get the pearl, for example poison the child, burn Kino's house, destroy his canoe and even try to kill Kino and his family. Even Kino himself is affected by the pearl.Although he plans to use it to better himself and his family situation, he becomes obsessed with it and turns violent, even againts Juana. Kino's anger turn to rage when he discovers that Juana is about to throw away the pearl. He beats her up and kicks her. Kino whom we first see as a loving and protective family man, is now more concerned about the pearl. All of these show how money can change people and the theme of greed is one of the themes found in this novel. Comment: Your answer needs to be written in paragraphs to make it more organized. Be careful of your grammar.

“GOD” and “DOG” Essay

Growing up, my summers were often spent at my uncle’s ranch. My mom would drive me up and leave me for about 2 to 3 weeks. Those were the most fruitful and fun-filled summers of my life. At the ranch, I would be far removed from city life and its hectic schedule. Instead, I would spend my mornings in bed, often waking up late to have a very fine breakfast prepared by my aunt. My cousins were very accommodating and my friendship with them remains to be part of my most-treasured memories. We still keep in touch by E-mail, and sometimes see each other when our schedules allow. Idyllic and fun as it was, the most â€Å"haunting† and persistent memory I have of those summers at the ranch is that of Evan. Evan is one of my uncle’s farm hands’ son, and although he was only slightly older than we were, he had already started working at the farm since he was eight or nine. His friendship helped shape the way I am now, and made a positive impact in my life. His story and friendship became a personal cause for me, and I am hoping I could lay it down to make it into a more public advocacy. * * * At first I thought his name was Moe, because my cousins called him â€Å"Slow Moe. † He was shy and kept to himself, and never went out of his way to talk to us. Mon, my eldest cousin, had another, and simpler, nickname for him: â€Å"Stupid. † I felt sorry for him. And maybe that was why I tried my best to befriend him. It was not easy at first, but then he cracked a smile and the conversation went smoothly after that. One thing that struck me about â€Å"Moe† was that he was actually intelligent. He knew his work, and was really passionate about the horses he tended to. He knew a lot of things about their nature, how to keep them, and how to pacify them if they were agitated. His knowledge also applied to other animals. We had a great time talking about a lot of other things: about his life, my life, current events, the news, and even the gossip around town. Just about anything and everything was up for discussion. Moreover, he had his own opinions about a lot of issues and I found that really admirable. Sometimes he taught me things like how to ride a horse, or how to jump into the lake without landing so painfully on my stomach. He also taught me about constellations, their names and how to identify them. I also found out his real name was Evan, but he had learned to live with â€Å"Moe†. One night, I ventured asking why he was not in school. Evan just chuckled and said that those kids were â€Å"evil. † I later found out that Evan attended up to the first grade and then refused to go back. His last day at school was an ugly episode wherein some kids in his class called him all kinds of names and beat him almost to death. My cousins initially resented the time I spent with Evan, and even the few times I brought him along with us. He was an outsider, they protested. And they were ashamed to be seen in town with the â€Å"farm hand† with â€Å"no lights on up there. † But Evan eventually won them over, and with my cousins realizing that they have been wrong with the guy, they developed a better relationship with him. Soon, his nickname was rarely mentioned among us, and we started using his real name. Evan is a dyslexic. During that time, however, he was just plain â€Å"stupid. † I doubt if his parents ever knew his condition or cared about it. Evan was taught at home by his mom, who used pictures and drawings to get herself understood. Evan was alright with verbal explanation, but not written ones. I learned about his condition when we ventured into town with my cousins and stopped by a bookstore. He was looking at the sign outside the store and read the sign as â€Å"bokos†. I laughed and he immediately fell silent. I sensed something was wrong, but I kept quiet about it until we reached home. Because we were already close friends by that time, I asked him about it.. He admitted that he â€Å"couldn’t read,† and I told him I could not believe that. He seemed to be a smart and intelligent person, there is no way he was illiterate. He shook his head and insisted that he could not read. He explained that when he read, he always read it wrong. Evan explained that to him, E, M, and W all looked alike, as well as G, O and D. So he reads â€Å"GOD† and â€Å"DOG† as â€Å"OOO†. He further said that there are times that he could see the letters, and know what they are, but that they â€Å"danced around†. Like if he sees the word CAT, he can identify the letters C, A and T, but he could not string it together. Sometimes he’d see it as C, A and T, sometimes it’s A, C, and T. * * * Dyslexia is a disability that affects an individual’s reading and writing skills, a condition that is present in 10% of the general population in various forms and degrees (Dyslexia Action, undated, online). Today, an estimated 15% of American students suffer from dyslexia, and up to half of all Americans have some form of undetected learning disabilities. Other studies also report that as many as 2. 9 million school-aged American children have learning disabilities (Edwards, 2006, online. ) Heather Hardie, citing dyslexia expert Sylvia Moody, writes that dyslexia is simply difficulty with writing and reading, which may stem from short-term memory weakness, faulty information processing, and weak perceptual, spatial and motor skills. A dyslexic, therefore, can have problems with poor concentration and poor memory. It may manifest subtly, like when a child is slow in reading certain words, but reads them correctly; or it may be severe and obvious like in Evan’s case. Dr. Moody adds that a dyslexic may exhibit other symptoms and problems like bouts of forgetfulness, difficulties in organization and in keeping time. (Hardie, 2006, p. 26). The overall effects are dramatic. To a child suffering from dyslexia, school work may suffer. Reading is such a basic skill that’s required in nearly all school subjects that a dyslexic child is put at a great disadvantage, and often leading to problems with learning. The child usually fails in school. It can also lead to low self-esteem, delinquency, aggression, behavioral problems, and social withdrawal (Mayo Clinic Staff, 2007, online). This was clearly seen in Evan’s case. He was extremely shy and preferred to work away from us and mostly kept to himself. This was unfortunate, because his friendship made my summers at my uncle’s farm more memorable. I hate to think how many friendships were not developed because of dyslexia. How many children had wanted to reach out and say hi, but was stumped by the fear of being laughed at. The moniker and label â€Å"dyslexic† is bad enough, but being thought of as â€Å"stupid† is a million times worse. A child with dyslexia needs a supportive environment both at home and at school. A parent should explain to the child that it is not his or her fault, and patiently explain the condition to him or her, this will enable the child to cope and compensate for his or her disability. Parents of dyslexic children should also get in touch with teachers, and it might help if they find support groups that can provide both emotional support and good information (Mayo Clinic Staff, 2007, online). Dyslexic students grow up to be dyslexic adults, and in the workplace, dyslexia is not much kinder to those who suffer from it. In fact, Linda Goldman and Joan Lewis (2007) writes that information processing disorders, like dyslexia and attention deficit hyperactivity disorder, are considered legal disabilities, giving the suffered adequate legal protection against discrimination and requires employers to ensure fairness by making â€Å"reasonable adjustments† in terms of recruiting, training, employing and promoting employees with dyslexia (p. 16). Often a dyslexic worker produces below par work output, manifests poor timekeeping, and often fails to remember instructions. This puts him or her at greater risk to be terminated from work, especially if his or her condition goes undiagnosed and unrecognized (Goldman and Lewis, 2007, p. 16). Even so, most employees with dyslexia need only more time to do their work and to correct problems related to concentration and coordination. This is what â€Å"reasonable adjustments† are all about (Goldman and Lewis, 2007, p. 16). However, I take heart in the stories of a lot of people who have succeeded in spite of having dyslexia. Pamela Coyle (1996) chronicles the travails and successes of three of them: Sylvia Ann Law, David Glass and Jonathan Pazer. All of them are noted dyslexics, yet each one succeeded in their fields. Sylvia Law became a professor of, appropriately, law. She also teaches medicine and psychiatry. She is the author of several books and has served as lecturer, as well as strong influence in the fields of civil rights and poverty law. David Glass and Jonathan Pazer are both practicing lawyers. (pp. 64-67). Heather Hardie (2006, p. 24) adds businessman Richard Branson, comedian Eddie Izzard and architect Richard Rogers to the list. Their lives are shining examples of how dyslexia could be overcome, if only one does not give in to low self-esteem and engage in self-pity. More than that, a child with dyslexia should grow up in a supportive environment that would not only foster his development, but also instill in him or her the confidence needed to grow and live life. * * * The last time I saw Evan was more than two years ago. He had become a handsome and confident young man, and has a steady girlfriend who, along with Evan’s mother, is helping him study for a high school equivalency test. At the time, he was also working at a local fast food chain as a janitor, and at the local school doing odd jobs. But Evan still shies away from contact and conversation with strangers. For my part, I am happy to have met him at a time when I was growing up. He made me think and realize that people have their own problems, and it is difficult to judge them by what we see. Moreover, he made me realize that what’s more important is what we do not see. If I had not scratched below the surface, I would still be one of those kids who continue to call him â€Å"Slow Moe,† and that would have deprived me of a friend who had made my summers at the farm richer and more fulfilling with his stories, tips, and jokes. In a sense, I know I could never thank Evan enough for the impact he had in my life. But I know that I am thanking him with every child, dyslexic or not, that I tutor on reading and writing as a volunteer for our neighborhood pre-school. I am thanking him by not being mean to other people when they show a kind of â€Å"weirdness† or â€Å"stupidity. † I am thanking him by not judging people I meet right away. I wish I could do more. I want to tell Evan the next time I see him all about Sylvia Law and other people whom I think would influence him to do better with his life despite his disability. In fact, I hope to be able to tell people just how wrong they are at labeling dyslexic people â€Å"stupid. † What they need is love and support. They need all the leeway they can get to help them overcome their disability. They have all the potential to succeed in life, if we—friends, teachers, fellow students, employers, colleagues, and parents—only give them the chance. Acknowledgments: First of all, I want to thank (name of teacher) for giving us this assignment. This exercise has given me the opportunity to think about my life and appreciate a person who I never really thought much about before. Alvin John for proofreading all those drafts and giving suggestions that helped shape this paper. And of course, Evan for the friendship and the insights. References 2007. Dyslexia: Complications. Retrieved July 11, 2008, from Mayo Clinic, Web site: http://www. mayoclinic. com/health/dyslexia/DS00224/DSECTION=complications 2007. Dyslexia: Coping and Support. Retrieved July 11, 2008, from Mayo Clinic, Web site: http://www. mayoclinic. com/health/dyslexia/DS00224/DSECTION=coping Coyle, Pamela (1996). What Sylvia Law, Jonathan Pazer and David Glass confront when they read or write. ABA Journal, 82, 64. Retrieved July 10, 2008, from ABI/INFORM Global database. (Document ID: 10121349).

Free Essays on Catch22

America has been involved in the cold war for years. The fear of communism is ruining lives. The country moves closer and closer to the Korean war. Joseph Heller’s Catch 22 is published. 1963- College students are seen wearing army fatigues with "Yossarian" name tags. Reports are being made about a "Heller Cult". Bumper stickers are manufactured which read, "Better Yossarian then Rotarian". The phrase "Catch 22" has surfaced meaning a "no win situation" it is now an excepted word in the English dictionary. Such a dramatic change in opinion from the earlier, Pro-war society, it is obvious that Catch 22 had some impact on the anti-war movement of the 1960’s-1970’s. Not to say the book was the one reason the movement started, It was certainly a catalyst. A protest novel, Heller’s story portrays the absurdity of bureaucracy, the stupidity of war, and the power they both have to crush the human spirit. Heller uses a war zone setting, to satirise society at larg e. He compares the commanding officers to Incompetent businessmen. "Don’t mumble, and mumble "sir" when you do, and don’t interrupt, and say "sir" when you do." Desiring promotion over every thing else, Colonel Cathcart keeps raising the number of missions the men of his squadron must fly. Even though the army says they need fly only forty, a bureaucratic trap called "Catch 22" says they can’t go home at forty because they must obey their commanding officers. Much like the work place, the men are forced to go through endless amounts of red tape, which hardly gets them anywhere. Yossarian tries to pretend he is crazy to get out of fighting. He signs "Washington Irving" on letters he censors, and walks around naked for a couple of days. If someone is crazy he needs only ask and he can be dismissed from duty. Yet, one would be crazy to fly, and only a sane person would ask to stop, Yossarian is therefore not crazy and is ordered to continue flying his missions. Hel ler also d... Free Essays on Catch22 Free Essays on Catch22 America has been involved in the cold war for years. The fear of communism is ruining lives. The country moves closer and closer to the Korean war. Joseph Heller’s Catch 22 is published. 1963- College students are seen wearing army fatigues with "Yossarian" name tags. Reports are being made about a "Heller Cult". Bumper stickers are manufactured which read, "Better Yossarian then Rotarian". The phrase "Catch 22" has surfaced meaning a "no win situation" it is now an excepted word in the English dictionary. Such a dramatic change in opinion from the earlier, Pro-war society, it is obvious that Catch 22 had some impact on the anti-war movement of the 1960’s-1970’s. Not to say the book was the one reason the movement started, It was certainly a catalyst. A protest novel, Heller’s story portrays the absurdity of bureaucracy, the stupidity of war, and the power they both have to crush the human spirit. Heller uses a war zone setting, to satirise society at larg e. He compares the commanding officers to Incompetent businessmen. "Don’t mumble, and mumble "sir" when you do, and don’t interrupt, and say "sir" when you do." Desiring promotion over every thing else, Colonel Cathcart keeps raising the number of missions the men of his squadron must fly. Even though the army says they need fly only forty, a bureaucratic trap called "Catch 22" says they can’t go home at forty because they must obey their commanding officers. Much like the work place, the men are forced to go through endless amounts of red tape, which hardly gets them anywhere. Yossarian tries to pretend he is crazy to get out of fighting. He signs "Washington Irving" on letters he censors, and walks around naked for a couple of days. If someone is crazy he needs only ask and he can be dismissed from duty. Yet, one would be crazy to fly, and only a sane person would ask to stop, Yossarian is therefore not crazy and is ordered to continue flying his missions. Hel ler also d...

Reporting on Meetings and Conferences in Journalism

Reporting on Meetings and Conferences in Journalism So you’re writing a news story that covers a meeting- maybe a  school board hearing or town hall- for the first time, and aren’t sure where to start as far as the reporting is concerned. Here are some tips to make the process easier.​ Get the Agenda Get a copy of the meeting’s agenda ahead of time. You can usually do this by calling or visiting your local town hall or school board office, or by checking their website. Knowing what they plan to discuss is always better than walking into the meeting cold.​ Pre-Meeting Reporting Once you’ve got the agenda, do a little reporting even before the meeting. Find out about the issues they plan to discuss. You can check the website of your local paper to see if they’ve written about any of the issues coming up, or even call members of the council or board and interview them.​ Find Your Focus Pick a few key issues on the agenda that you will focus on. Look for the issues that are the most newsworthy, controversial or interesting. If you’re not sure what’s newsworthy, ask yourself: which of the issues on the agenda will affect the most people in the community? Chances are, the more people affected by an issue, the more newsworthy it is. For example, if the school board is about to raise property taxes 3 percent, that’s an issue that will affect every homeowner in your town. Newsworthy? Absolutely. Likewise, is the board is debating whether to ban some books from school libraries after being pressured by religious groups, that’s bound to be controversial and newsworthy. On the other hand, if the town council is voting on whether to raise the town clerk’s salary by $2,000, is that newsworthy? Probably not, unless the town’s budget has been slashed so much that pay raises for town officials have become controversial. The only person really affected here is the town clerk, so your readership for that item would probably be an audience of one.​ Report, Report, Report Once the meeting’s underway, be absolutely thorough in your reporting. Obviously, you need to take good notes during the meeting, but that’s not enough. When the meeting has ended, your reporting has just begun. Interview members of the council or board after the meeting for any additional quotes or information you might need, and if the meeting involved soliciting comments from local residents, interview some of them as well. If an issue of some controversy came up, be sure to interview people on both sides of the fence as far as that issue is concerned.​ Get Phone Numbers Get phone numbers and email addresses- and, depending on your style guide, home towns and ages- for everyone you interview. Virtually every reporter who’s ever covered a meeting has had the experience of getting back to the office to write, only to discover there’s another question they need to ask. Having those numbers on hand is invaluable.​ Understand What Happened Remember, to produce solid meeting stories, never leave a meeting without understanding exactly what happened. The goal of your reporting is to understand what exactly happened at the meeting. Too often, beginner reporters will cover a town hall hearing or school board meeting, dutifully taking notes throughout. But in the end, they leave the building without really understanding what they’ve just seen. When they try to write a story, they can’t. You can’t write about something you don’t understand.

Organisational Change Case Study Example | Topics and Well Written Essays - 2500 words

Organisational Change - Case Study Example Since its inception in 2003, the company found itself as relatively young in the industry. However it emerged as a market leader in the industry going over 225 destinations with 6 cruises. The company has taken the necessary strategies to ensure that it responds to the external changes in the industry. It is one of the leading players currently in the cruise industry and has been able to create a competitive edge in the industry which many operators have not been able to create although they have been in the industry for along time now. The company is serving more than 2050 passengers going for journeys of more than 100 nights in the sea. The company has already expressed its interest in Asia and European markets.Like other companies P & O Cruise was challenged by the changes that were taking place in the external environment. Let us look at some of the changes that led to implementation of the current changes in the operation of the company that affected the tourism industry. One of the security threats that have affected the industry has been the issue of terrorism. The attacks by IRL in Britain’s transport industry have been one of the threats that the industry has been facing. Many people have feared that the attacks would be diverted from railway travelling system to the cruise industry. But the September 11 attack in the US affected the industry in a way that all people feared travelling. The subsequent attack of the British Railway system on July 7th was like a final blow to the industry. There were record low booking in the cruise industry. Social changes The cruise industry has been led by the social changes taking place in the market. Changes in customer's preference have been instrument in instating social changes that have affected the operations of the cruise industry. Since 1997, it has been observed that there has been more preference to group and family travelling in the cruise industry. Technological changes Cruise industry has been forced to respond to technological changes that directly or indirectly affects the industry. Since 1997, technology has reduced face to face business transaction especially in making the bookings. Many people also take their holidays and at the same time continue with their business. Environmental changes There have been changes in the marine pollution laws that have made the industry to put in place new strategies in order to manage these changes and operate within the new marine pollution laws. Several laws have been put in place by International Maritime Organization which has affected the industry. Political and government policies New legislation concerning the maintenance of ports and the subsequent new changers that have been put in place has been a challenge to the industry. Acts like Crimes at Sea Act 2000 and others like Admiralty Act has continued to be a challenge for the industry. (Jolene 2000, p. 4)) Political stability has been a big challenge for the

Singapore Airlines Case Essay Example | Topics and Well Written Essays - 1000 words

Singapore Airlines Case - Essay Example The management came up with a policy of recruiting young people between the ages of 20 – 25 who had completed high school level and had â€Å"O levels in English†. Young crew policy had some advantages. Young crew who were recruited was most likely to depict some sense of enthusiasm and keenness in their work. In addition, they were fit physically to manage the demanding job and to meet the thorough schedule. Furthermore, it was believed that most of the passengers enjoyed being served and attended by young and attractive men and women. Another implication of using young crew policy was that it reduced the substantial size of the applicant pool. This was because young people had the opportunity of studying in the university or getting other kinds of education thus reducing the number of desirable school leavers. The policy also provided opportunities for ensuring that the crew remained young by offering the five-year renewable contract to the crew. This policy also offered a career path and a possibility of a lifetime employment contract to the stewards. Those who were recruited were given six-week training before being considered as qualified operational crew. The training covered such areas as personal grooming, poise, uniform care and also personal conduct. Practical lessons commenced by learning the names and purposes of all the available amenities available on the airline board. Other lessons dealt with various types of service ware, glasses, dishes and other food serving items that might be used by the crew. Recruits were also taught of names and procedures for various drinks and dozens of food items served by the SIA. The training also covered some classes on how to handle emergencies and incidents on board. The performance of the crew was formally evaluated through staff interviews and also based on comments from the passengers. The performance report was based on three evaluations.  First, flight stewards were appraised by senior flight stewards and stewardesses working on the same flight.